Buddies Pepper Lewis (Woody Harrelson) and Sonny Gilstrap (Kiefer Sutherland) who are championship rodeo partners travel to New York to find their missing friend, Nacho Salazar Joaquín Martínez after he disappears in New York City to pick up his daughter, Theresa (Cara Buono). When Pepper and Sonny find that neither is anywhere to be found, they go about the wacky adventure of finding Nacho and Theresa, and in the process, test the foundation of their friendship. Along the way, they find...

Marcus Burnett is a hen-pecked family man. Mike Lowry is a foot-loose and fancy free ladies' man. Both are Miami policemen, and both have 72 hours to reclaim a consignment of drugs stolen from under their station's nose. To complicate matters, in order to get the assistance of the sole witness to a murder, they have to pretend to be each other.